Medically reviewed by: Dr. Jeffrey Galvin & Ariel Curtis, FNP-C
Hyaluronic acid is a gel-like substance naturally found in joint fluid. In the knee, it helps lubricate and cushion the joint during movement. When osteoarthritis develops, the joint may lose some of this natural cushioning, leading to stiffness, friction, and reduced mobility.
Hyaluronic acid injections, also called viscosupplementation, are designed to supplement the joint’s natural fluid and support smoother movement in the knee.
The exact mechanism of action is not fully understood, but research suggests multiple benefits:
The injected hyaluronic acid increases the viscosity of synovial fluid, reducing friction between cartilage surfaces.
Hyaluronic acid may suppress inflammatory cytokines and reduce the production of enzymes that degrade cartilage.
Some evidence suggests hyaluronic acid injections may stimulate the body’s own production of hyaluronic acid.
By improving joint mechanics and reducing inflammation, hyaluronic acid may help slow cartilage degeneration.
Unlike corticosteroid injections, which provide rapid but temporary anti-inflammatory effects, hyaluronic acid injections work more gradually but can offer longer-lasting relief.
Hyaluronic acid injections are commonly used for mild to moderate knee osteoarthritis. They may help improve joint lubrication, reduce stiffness, and support better movement.
For patients with knee arthritis symptoms that come and go, hyaluronic acid injections may be part of a non-surgical plan to support comfort and mobility.
When knee stiffness or joint friction affects walking, stairs, or daily activity, hyaluronic acid injections may help support smoother joint movement.
Hyaluronic acid injections may be recommended for patients who want to delay or avoid surgery and continue managing knee osteoarthritis with conservative care.
Several hyaluronic acid products are available, differing in molecular weight, number of injections required, and duration of effect. Your provider will select the product best suited to your condition.
| Product | Treatment Format | Duration |
|---|---|---|
| Orthovisc | 3–5 series hyaluronic acid injection | 6–12 months |
| Hyalgan | 3–5 series hyaluronic acid injection | 6–12 months |
| GenVisc | 3–5 series hyaluronic acid injection | 6–12 months |
| Monovisc | 1 series single-injection hyaluronic acid option | 6–12 months |
| Durolane | 1 series hyaluronic acid injection | 6–12 months |
The choice depends on the joint, severity of arthritis, patient preference, and insurance coverage.
Hyaluronic acid injections may help support smoother knee movement by improving lubrication and cushioning within the joint.
Hyaluronic acid injections are generally well tolerated. Some patients may experience mild, temporary effects around the treated knee.
Results vary by patient, product used, and severity of knee osteoarthritis. Some patients may notice improvement for several months, while others may need a repeat series based on provider guidance and symptom response.
| Feature | Hyaluronic Acid | Cortisone |
|---|---|---|
| Mechanism | Lubrication, shock absorption, and mild anti-inflammatory effects | Potent anti-inflammatory |
| Onset of relief | 2–4 weeks, gradual | 24–72 hours, rapid |
| Duration | 6–12 months | Weeks to months |
| Best for | Mild to moderate osteoarthritis and chronic management | Acute flare-ups and severe inflammation |
| Frequency | 1 injection or series every 6–12 months | Limited to 3–4 per year |
| Effect on cartilage | May be chondroprotective | Potential damage with excessive use |
In some cases, we combine both approaches: a cortisone injection for rapid relief of a flare-up, followed by hyaluronic acid to provide longer-term lubrication.
Expert Providers
Dr. Jeffrey Galvin and Ariel Curtis, FNP-C, have extensive experience in viscosupplementation and image-guided injections.
Image Guidance
All injections are performed under ultrasound or fluoroscopy for accuracy and safety.
Personalized Care
We select the hyaluronic acid product and injection protocol best suited to your condition.
Comprehensive Approach
Hyaluronic acid is often combined with physical therapy, weight management, and regenerative medicine for optimal outcomes.
Convenient Charlotte Location
Serving patients from Charlotte, Huntersville, Concord, Matthews, and surrounding areas.
Most patients feel a brief pinch or pressure during the injection. The procedure is generally well tolerated. Mild soreness after the injection is common and usually resolves within a few days.
Unlike cortisone, hyaluronic acid works gradually. Most patients notice improvement within 2–4 weeks after completing the injection series. Full benefit is often seen at 6–8 weeks.
The effects typically last 6–12 months. Some patients may experience relief for longer. When symptoms return, a repeat course can be considered.
Yes, but we typically wait at least 4–6 weeks after a cortisone injection before administering hyaluronic acid. Spacing them out allows for a more predictable response.
It depends on the product. Some require a single injection, while others are given as a series of 3 or 5 injections one week apart. Your provider will recommend the appropriate protocol.
Yes. Hyaluronic acid injections do not affect blood sugar the way cortisone can. They are a safe option for diabetic patients with osteoarthritis.
The most common side effect is temporary pain or swelling at the injection site. Rarely, a more significant inflammatory reaction can occur, but it is usually self-limited. Infection is extremely rare.
For many patients, yes. By managing pain and improving function, hyaluronic acid injections can postpone or even eliminate the need for joint replacement. They are most effective in mild to moderate arthritis.
You may be a candidate if you have mild to moderate knee or other joint osteoarthritis, pain persists despite physical therapy, weight loss, and oral medications, you want to avoid or delay joint replacement, or you want a non-surgical option with longer-lasting relief.
If you have knee or joint arthritis and want to explore hyaluronic acid injections, schedule a consultation at Joint Health Solutions in Charlotte. We will help determine if viscosupplementation is right for you and integrate it into a comprehensive care plan.
